Research Methods in Neurochemistry: Volume 4
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Causative polygenic pathomechanisms of disease coexist with pleiotropic consequences of a single genetic variation influencing multiple phenotypic expression patterns. To date, scarce evidence supports the role of polygenic mechanisms in self-consciousness, but details of candidate genes, influencing factors as well as potential overlap remains to be fully elucidated for most of its constituent processes.
The role of neurotransmitters in emergence and modulation of self-consciousness is robustly supported by early studies on drug-induced altered states of consciousness. How to approach the interaction between principal transmitters, such as glutamate and GABA, which balance the general level of brain activity, with modulatory transmitters, e.
Biochemistry and Molecular Biology
Shall the research be restricted to identification of endogenous transmitters and their receptor pathways, or shall intracellular processes also be targeted such as ligand-dependent signalling cascades in accordance to the functional selectivity hypothesis of neuromodulation already investigated in animal model psychosis research?
And most importantly, which are the links between self-related circuit function and genetic variants, which are related to neurotransmitter signalling? The current Research Topic represents an unique opportunity to call attention to this widely neglected molecular approach to self-consciousness, gathering new evidence for novel concepts, and opening debate for future directions of research in the field.
We welcome articles from all domains of neuroscience research, including e.
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All types of articles are accepted, original research, methods, hypothesis, theory and opinions. Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author. Research Topic The molecular self: genetics and neurochemistry of self-consciousness. Submission closed.